Selenium is used as an anti oxidant mineral, More specifically used for Cancers, particularly prostrate and female organ cancers as well as rectal and colon cancers, it is also used to balance thyroid hormones, balancing male and female hormones.
The Selenium-Cancer Connection
Since the 1980s, most of the selenium research has been in the area of cancer prevention. The first study was conducted by Combs, Whitacre's thesis adviser at Cornell University.The late Larry C. Clark, Ph.D., and former director of the Arizona Cancer Center's epidemiology program at the University of Arizona, was another Cornell researcher.
"In 1983, which was my last year at Cornell, [Combs and Clark] started a 10-year study looking at 200 micrograms (mcg) per day of selenium supplementation using high selenium yeast compared to no supplementation …
They found … there was a 50 to 63 percent reduction in cancer rates in colon, lung and prostate, with the highest number of 63 percent rate reduction in prostate cancer …
That was probably the first study that really looked at the impact of selenium supplementation on cancer reduction. Since that point, there's been dozens of studies verifying that work," Whitacre says.
"That work really emphasized … the thought that the glutathione peroxidase reducing free radical production was the biological role. There is some newer work that looks like there may possibly be another function … beyond the antioxidant role of glutathione peroxidase …
Most of the works since [then] has really been looking more at selenium form. That study used SelenoExcell high-selenium yeast, and there's been several studies that have looked at sodium selenite [and] selenomethionine, and have not seen the same effect … [F]orm does make a difference.
The SelenoExcell high-selenium yeast has been the most effective form. Matter of fact, selenomethionine had no effect in a very long term cancer research study published in 2011 called the SELECT trial …"
The Form of Selenium You Use Is Very Important
Interestingly, there does not appear to be a significant difference between selenium forms in regard to the amount of glutathione being produced. However, it makes a big difference when you're looking at cancer incidence. Selenomethionine is a single amino acid where the selenium has replaced the sulfur in methionine. High selenium yeast is the full protein form, and a more natural food form.The selenium yeast gives you not just selenomethionine but also methylselenocysteine and selenocysteine. Research suggests methylselenocysteine may be the most active form in reducing cancer, and that's the form found in high-selenium yeast. It's not found in selenate, selenite or selenomethionine.
"When you look at the selenium bounty yeast, it does match with the selenium that you see in tuna, for example, or that you see in natural plant forms. It does match more the natural food form, which is in the complete protein form. We don't know [whether] the protection of the protein makes it more effective, or [if it's] the form itself that's in the selenium yeast beyond selenomethionine.
The selenium in selenium yeast has been shown to be about 70 percent selenomethionine. But these other forms that are in the yeast form — and also in Brazil nuts — does have the methylselenocysteine and also selenocysteine that you don't have in these other selenium forms.
It's really thought at this stage that the mixture of these forms … like selenomethionine together with methylselenocysteine and selenocysteine, could possibly be the reason why it's more effective than selenomethionine by itself at … 200 mcg."
As per recommendation on the package. 1-3 capsules a day with MEALS
Ingredients per capsule
Precaution: Long term use of more than 600iu per day may have adverse consequences. Children should receive proportionally smaller doses